Loved since 1908. Clinically proven to help freshen breath. As effective as brushing (When fed daily, Milk-Bone Brushing Chews are as effective as brushing a dog's teeth twice a week based on the reduction of tartar build-up and bad breath. The Veterinary Health Council recommends daily tooth brushing for optimal effectiveness). Advanced oral care with fresh breath. Helps give your dog a healthy, happy life. Nubs & ridges designed to help clean like bristles on a toothbrush. Fights tartar build-up and bad breath. Daily Milk-Bone Brushing Chews. Yearly veterinary dental checkup. As effective as brushing (When fed daily, Milk-Bone Brushing Chews are as effective as brushing a dog's teeth twice a week based on the reduction of tartar build-up and bad breath. The Veterinary Health Council recommends daily tooth brushing for optimal effectiveness) helps clean even hard to reach black teeth and down to the gumline. See bottom panel for details. VOHC accepted. Veterinary Oral Health Council. Helps control tartar. For dogs 50 lbs or more. Not suitable for dogs less than 50 lbs or dogs less than 6 months of age. Fortified with essential vitamins and minerals, including calcium to help support strong bones and teeth. Calorie Content (Calculated): Metabolizable Energy (ME) 2580 kcal/kg; 99 kcal/piece. Comments or questions? Call 1-888-Milkbone (645-5266), Weekdays. Please provide product manufacturing code. www.milkbone.com. Produced in Topeka Kansas, USA.